N-acetylcysteine relieves neurologic signs of acute ethanol hangover in rats

Introduction: Alcohol abuse is one of the grave social and medical problems in many countries, including Russia. not only negatively affects health, family relationships, but also a person’s performance. Hangover, which negative consequences alcohol intake, complex neurological somatic symptoms that occur when ethanol almost completely metabolized to acetaldehyde. This condition, despite severity potential economic damage, remains poorly understood, there are no effective medicines treat it.
 Aim: provide an experimental basis for possibility using N-acetylcysteine (NAC), precursor glutathione, as medicine prevention cognitive impairments due intoxication.
 Materials Methods: The study used male Wistar rats, were intraperitoneally injected with at dose 3 g/kg simulate acute intoxication. Sixty minutes before injection, animals from groups gavaged NAC (1 g/kg) or equivalent volume saline. Immediately after awakening h it, assessed deficits, motor skills, spontaneous activity, functions. After completion behavioral tests, euthanized assess level triglycerides (TGs), malonic dialdehyde (MDA) liver homogenates, determine activity enzymatic antioxidant systems serum aminotransferases.
 Results Discussion: intoxication control group was associated pronounced signs impairments, low exploratory impaired fine skills adhesive test, function decline Morris water maze test. rats had received injection demonstrated better higher performance test (in comparison treated saline intoxication). In NAC, levels MDA, TGs, well enzymes, closer values intact greater extent than been saline.
 Conclusion: Orally administered led decrease deficiency reduced amnesic effect ethanol. could be improvement metabolism disorders oxidative stress dysfunction.